Antifungal Proteins

Antifungal proteins.

Efflux pump proteins in antifungal resistance

It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of Cdr1p and/or CaMdr1p belonging to ABC and MFS superfamilies, r...

Plant-derived antifungal proteins and peptides.

Plants produce potent constitutive and induced antifungal compounds to complement the structural barriers to microbial infection. Approximately 250,000-500,000 plant species exist, but only a few of these have been investigated for antimicrobial activity. Nevertheless, a wide spectrum of compound classes have been purified and found to have antifungal properties. The commercial potential of eff...

Apoptosis-inducing antifungal peptides and proteins.

Despite the availability of various classes of antimycotics, the treatment of patients with systemic fungal infections is challenging. Therefore the development of new antifungals is urgently required. Promising new antifungal candidates are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that ind...

Extending the benefits of antifungal proteins from plants

One of main challenges of growing crops successfully comes from the natural enemies of plants including viral, bacterial and fungal pathogens. The dependence in agriculture on synthetic agrichemicals including antimicrobials is undoubtedly important but not sustainable for the sake of the environment in the long run. In this chapter, it is noted that there is a large number of papers showing th...